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Epilepsy is a brain disorder caused by unusual brain activity resulting in unusual behavior of the patient, or seizures. Usually, the brain sends messages to the body nonstop to achieve a purposeful response. When brain activity becomes excessively abnormal, it results in an abnormal bodily response. This can also occur because of the presence of other medical conditions including low blood sugar. Therefore, to make a definitive diagnosis of epilepsy, all the medical conditions must be ruled out. Epilepsy is also classified according to the involvement of the entire brain or part of the brain. Worldwide, almost 50 million people are affected with epilepsy.
It is unclear what causes epilepsy in most cases, however, it is sometimes caused by a head injury, tumor, infection, or cerebral vascular accident. Many characteristics can increase a patient's risk for epilepsy. Most patients that are diagnosed with epilepsy will have multiple seizure events without a known cause. There are also treatment types that should be used based on the patient's suitability. Epilepsy can cause a lot of psychological difficulties and therefore proper education and counseling for the patients and caregivers is also part of the patient's treatment plan.
What Is Epilepsy?
Epilepsy is an ongoing (chronic) condition that causes repeated episodes of seizures from abnormally high levels of electrical discharges produced by damaged brain cells. Seizures occur with a burst of abnormal electrical activity in the brain. Seizures can involve changes in awareness, muscle control (muscles may twitch or jerk), sensations, emotions and behavior.
Epilepsy is also called a seizure disorder.
What Happens In Your Brain When You Have Epilepsy?
The cells in your brain act as messengers to and from all parts of your body. These messages convey information via an ongoing electrical impulse, which moves from cell to cell. Epilepsy interferes with this driving rhythm of electrical impulses. Instead, there are bursts of electrical energy - like an unpredictable electrical storm - between cells in one or more regions of your brain. This disorganised electrical activity results in changes in your awareness (including loss of awareness), sensations, emotions and movement.
The classification of a seizure depends on which area and how extensive an area of the brain is involved, and what occurs to the individual during the seizure event. Seizures can be divided into two categories: generalized seizures (absence, atonic, tonic-clonic, myoclonic) and partial (simple and complex) seizures, both of which may happen to individuals who have seizures in childhood. There are several subtypes within the generalized and partial seizure categories in childhood, including:
Medication
Certain drugs are taken in epilepsy to manage the symptoms and those drugs are called Antiepileptic medications. These medications alter brain activity to prevent the uncontrolled behavior of patients.
Surgery
In cases when the medication is not responsive or effective action surgery is used to manage the symptoms of epilepsy. In surgery either part of the brain is taken out that is causing the symptoms or a device is placed in the brain to control the activity of the brain.
Dietary therapy
For some young or children patients diagnosed with epilepsy it is recommended to take a diet that is rich in fats. Fats are essential for brain development.
Vagus Nerve Stimulation (VNS)
In this approach, a device is implanted in the chest that emits signals to the vagus nerve in the neck. This nerve stimulation will lessen how severe seizures are; that is it will reduce how frequent seizures are.
Responsive Neurostimulation (RNS)
RNS is another implanted device that monitors abnormal brain activity and delivers signals to suppress seizures once it detects those patterns of abnormality.
Lifestyle Changes
Seizures can also be managed with lifestyle changes. Avoiding any activity that is known to induce epilepsy, sleeping adequately and managing stress can also help suppress or eliminate episodes of seizure.
The cost of Epilepsy Treatment in India for Indian patients is approximately USD 1,980 – USD 2,640, while the cost for International patients ranges between USD 2,970 – USD 3,630. The cost may vary based on each patient's condition and the underlying reasons for epilepsy, in addition to the cost of Epilepsy Treatment, which can depend on the facilities of the hospitals and the competency of the healthcare professionals.
Causes
Epilepsy occurs when alterations in the brain make it overly excitable or irritable. This causes the brain cells to fire abnormal electrical signals. This process creates multiple seizures that are episodic and unpredictable (a seizure that occurs once and never again is not epilepsy).
Epilepsy can be caused by a medical condition or injury that changes the brain; however, it may not have a known cause (idiopathic).
Common reasons for epilepsy are:
Epileptic seizures can happen to anyone, at any age. However, they are frequent in young children and older adults aged 65 years or older, regardless of family history of seizures or epilepsy.
Symptoms
Individuals may express different symptoms. Some individuals may have basic staring episodes. Others may experience uncontrollable shaking and alterations in awareness (or convulsions). The type of seizure varies by which part of the brain is involved.
Most of the time, the seizures occurring in people with epilepsy will mimic prior seizures. A subset of people with epilepsy will have a strange sensation before each seizure. The phenoemenon can be tingiling of the skin, smelling an odor which is not really there, or other changes in emotions. This is an aura.
Your health care provider can tell you more about the specific category of seizure you have:
Absence seizures (also known as non-motor seizures) consist of seizures with a change in behavior without changing motor movement (ex. staring episodes). Absence seizures can happen along with generalized seizures.
A focal-onset seizure may occur without any change in awareness. Specific symptoms depend on the part of the brain that is affected. A focal-onset seizure can spread to the whole brain.
A generalized-onset seizure will lead to a seizure involving both sides of the brain and altered awareness. Abnormal movement of the whole body is usually present. There may be involuntary clenching of the jaw and loss of control over urine or bowel movements.
Risk factors for epilepsy include the following:
Family History of Epilepsy
A family history of epilepsy is a risk factor for epilepsy. A family member or very close relative with epilepsy can increase the risk of developing the disease.
Head Injury or Trauma
Head injuries caused by accidents or a fall can also lead to epilepsy. The victim has an even greater risk of developing epilepsy if the accident resulted in some damage to the brain.
Brain Infections
Brain infections create a higher risk of developing epilepsy. This infection can create a high fever and swelling which increase the possibility of the disease occurring.
Stroke or Vascular Disease
Loss of blood flow to the brain or damage of the brain tissue from a brain attack or damage to your brain's blood vessels are also risk factors for developing epilepsy.
Brain Tumors
Brain tumors can also disrupt the normal functioning of the brain and lead to an increased risk of epilepsy.
Developmental Brain Disorders
Disorders that affect the development of the brain can lead to an increased risk of epilepsy. These conditions typically occur in children, usually between infancy and five years of age.
Degenerative Conditions
Some degenerative brain disorders can bring about changes in the brain that may increase the risk of seizures. For instance, in old age, memory loss due to degeneration may lead to epilepsy.
Drug & Alcohol Use
Some medications are associated with an increased risk of epilepsy and people who use more alcohol than is recommended are at greater risk of developing epilepsy.
Childhood Febrile Seizures
Having febrile seizures during childhood can lead to a slightly greater risk of developing epilepsy later in life.
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