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A form of cancer known as Hodgkin's disease affects blood cells, which are a component of the body's natural defence mechanism. Because the white blood cells affected by Hodgkin's disease are known as lymphocytes, the disease is sometimes referred to as Hodgkin's lymphoma.
This condition is characterised by the overproduction of certain white blood cell types in the body, which are also behaving abnormally. Anomalies in white blood cells prevent them from participating in the defence system and from fending off the body's dangerous chemicals.
As a result, the immunity of patients is weakened, making them susceptible to diseases of various origins. Symptoms of the disease can manifest differently in patients, depending on the severity and extent of the disease. Some risk factors increase the likelihood of developing Hodgkin's lymphoma, and individuals with these risk factors should avoid them to reduce the risk of the disease. However, anyone can develop Hodgkin's lymphoma, regardless of whether they have risk factors.
Hodgkin's lymphoma can now be diagnosed and treated using advances in technology that allow for assessment and treatment in early stages and the possibility for [complete and permanent] cure. The treatment for Hodgkin's disease will depend on the type of Hodgkin's lymphoma, and it is common for a combination of treatments to be used with complicated cases.
Indian individuals with Hodgkin lymphoma should expect to pay between USD 1,200 and USD 1,600 for treatment. For overseas patients, the price ranges from $1,800 to $2,200. The type of treatment employed for a particular patient can affect the cost. The cost may also vary depending on the stage of the cancer at the time of diagnosis.
What Is Hodgkin Lymphoma?
Previously referred to as Hodgkin's disease, Hodgkin lymphoma is a type of blood malignancy that arises in the lymphatic system. It is among the two primary forms of lymphoma. Non-Hodgkin lymphoma is the other type. Your immune system's vital white blood cells, known as lymphocytes, are impacted by these tumours.
A mutation, or change, in the genes of B lymphocytes (B cells) at some point in your life can result in Hodgkin lymphomas. The lymph nodes in your neck or chest cavity are usually where Hodgkin lymphomas begin. They can also form in your groin, abdomen, or pelvis, or clusters of lymph nodes beneath your arms.
More people with Hodgkin lymphoma are living longer each year as a result of treatment. Hodgkin lymphoma can often be cured with treatment, resulting in the complete removal of all symptoms. Nevertheless, this illness can recur occasionally. Medical professionals are researching new therapies for this situation.
Each of the four forms of Hodgkin's lymphoma shares Reed-Sternberg cells as a standard component. The following are among them:
Nodular Sclerosis HL
With 60% to 80% of cases, nodular sclerosis is the most prevalent form of Hodgkin's lymphoma among patients. Nodular sclerosis typically begins in the neck, lymph nodes, or chest and is usually identified in its second stage. It usually affects adults and teenagers between the ages of 15 and 35. Furthermore, the condition affects an equal proportion of males and women.
Mixed Cellularity HL
The most common type of Hodgkin's lymphoma in patients is mixed cellularity Hodgkin's lymphoma (HL), which is followed by nodular sclerosis Hodgkin's lymphoma. The majority of the time, it happens to elderly persons who are infected with HIV. Additionally, mixed cellularity Hodgkin lymphoma (HL) may originate in the lymph node and spread to the upper body. It is observed that the spleen and abdominal lymph nodes are frequently affected.
Lymphocyte-rich Classic HL
Rich in lymphocytes, the disease is traditionally found in only 5% of cases, with Hodgkin lymphoma (HL) being the most common type. It affects men more frequently than Nodular Sclerosis, especially in older people. Rich in lymphocytes, the traditional Early detection is the most common way to detect Hodgkin lymphoma (HL), which usually manifests as symptoms in the armpits, neck lymph nodes, and above the collarbone.
Lymphocyte-depleted HL
Lymphocyte-depleted HL is prevalent in older adults and primarily in males with HIV infection, but it only makes up 1% of all instances of Hodgkin's lymphoma. It affects tissues such as the liver, bone marrow, and lymph nodes in the spleen and abdomen.
After making a Hodgkin lymphoma diagnosis, your doctor will stage your illness based on test results. Healthcare professionals can use cancer staging to ascertain the cancer's stage, potential rate of spread, and most effective treatment options. The Hodgkin lymphoma stages are as follows:
Stage I: One lymphoid organ, such as your thymus, spleen, or bone marrow, has cancer cells in it. Alternatively, a single organ outside of the lymphatic system may have lymphoma in a single location.
Stage II: Two or more groups of lymph nodes on the same side of your diaphragm have cancer cells in them; other lymph nodes close to your diaphragm may also be affected.
Stage III: You have cancer cells in the lymph nodes above your diaphragm and spleen, or lymphoma cells in the lymph node sections on each side of your diaphragm.
Stage IV: Your liver, lungs, or bone marrow are among the organs outside of your lymphatic system where you have lymphoma.
To categorise Hodgkin lymphomas according to their likelihood of responding well to treatment and remaining in remission (exhibiting no signs or symptoms of cancer), providers also employ labels such as "favourable" and "unfavourable."
Chemotherapy
One kind of treatment is chemotherapy, in which certain medications are used to either kill or stop the growth of cancer cells. Depending on the stage of the cancer and each patient's health, chemotherapy is used.
Radiation Therapy
X-rays or other high-energy radiation are used in radiation therapy to target and kill cancer cells or tumours. It is primarily used to enhance patients' responses when combined with chemotherapy.
Stem Cell Transplantation
In certain instances, the course of treatment may include a stem cell transplant. Healthy stem cells are used in this treatment to replace damaged bone marrow. This can help alleviate the patients' symptoms and support the newly transplanted stem cells in producing normal blood cells.
Immunotherapy
Immunotherapy drugs help patients resist cancer by boosting their immunity and strengthening their body's defences against the disease. It can be applied when the illness is still in its early stages.
Targeted Therapy
The purpose of targeted therapy is to target chemicals that are unique to cancer cells specifically. This method of treatment enhances the precision of targeting cancer cells while minimising the risk of harming healthy cells.
Surgery
The development of Hodgkin's disease can lead to the removal of tumours from the body through surgery. Additionally, it can be used to investigate tumours and identify the disease.
|
Treatment Costs in India |
Min |
Max |
|
Hodgkins Disease Treatment |
1066 USD |
1421 USD |
|
Stem Cell Transplant |
7992 USD |
10656 USD |
The most typical initial symptom of Hodgkin lymphoma is enlarged, painless lymph nodes in the groin, underarm, or neck. Other signs and symptoms include:
Fever, unexpected weight loss, and intense night sweats are referred to as "B symptoms" by medical professionals when discussing lymphoma. Your physician can plan therapies and assess your prognosis (the anticipated course of your health) based on the presence or absence of these symptoms.
Hodgkin's Lymphoma: Causes
The specific cause of Hodgkin's lymphoma has not yet been determined by medical research. Nonetheless, some have been frequently observed in individuals who suffer from the same condition. They're:
The aetiology of infectious mononucleosis has also been identified as a particular type of virus. We call it the Epstein-Barr virus. It has been noted that 20% to 80% of Hodgkin's lymphoma tumours contain the virus's genome.
Identical twins or siblings of the same sex who have the same tumour have also been found to have Hodgkin's lymphoma. This tumour is likely to be present in the child even if one of the parents has it.
Hodgkin's lymphoma is also brought on by several other factors, such as early birth order, single-family houses, and having fewer siblings. This issue also affects those who are not frequently exposed to bacterial and viral diseases.
Hodgkin’s Disease can be diagnosed in any one of the following methods:
Blood Testing
Blood testing is used to look for any abnormalities in the blood cells. It can also detect an abnormal elevation of the white blood cells.
Imaging Studies
Sometimes, a combination of imaging tests is performed to detect abnormalities in the structures.
Standard imaging procedures may consist of:
Computed Tomography (CT) Scan: This will provide detailed images of the body and the tissues involved with the disease.
Positron Emission Tomography (PET) Scan: PET scans may help to find locations of activity heightened by the atypical division of cancerous cells.
X-rays: X-rays can be used to help evaluate specific areas.
Biopsy
A biopsy is a diagnostic procedure that may confirm Hodgkin's disease. The biopsy procedure involves removing a small piece of tissue from the affected area. There are two types of biopsies:
Excisional Biopsy: This biopsy test is the complete removal of the enlarged lymph node or other affected tissue.
Needle Biopsy: This type of biopsy uses a needle to remove a small sample of the tissue.
Lymph Node Examination
A technician inspects the biopsy sample after it is delivered to a lab. The results of this test reveal whether Hodgkin's lymphoma or another illness is present.
Some of the risk factors of Hodgkin’s disease are:
Age
The majority of persons with Hodgkin's disease are young adults between the ages of 15 and 35, or older adults above the age of 55.
Gender
Males are more likely to develop Hodgkin's disease since the condition is more common in men.
Family History
Individuals are more likely to get Hodgkin's disease at any point in their lives if they have close family members who have it.
Viral Infection
The emergence of Hodgkin's disease is linked to certain different kinds of infections, particularly viral infections.
Weakened Immune System
Hodgkin's disease is more likely to strike people with weakened immune systems or those whose immune systems have been weakened by illness or pharmaceutical usage.
Exposure to Certain Chemicals
Long-term exposure to certain dangerous substances can raise the risk of developing Hodgkin's lymphoma.
Radiation Exposure
Individuals who are subjected to high-energy radiation for work-related or other reasons are susceptible to cancer, particularly Hodgkin's disease.
Obesity
There may be a connection between obesity and a higher incidence of Hodgkin's disease, according to some research.
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Hodgkin lymphoma, sometimes referred to as Hodgkin's disease, is a kind of cancer that impacts the body's immune system's lymphatic system. It starts when lymph nodes and other healthy cells in the lymphatic system expand and proliferate abnormally. Although it can happen to anyone at any age, young adults and elderly individuals are the most likely to experience it.
Indian individuals with Hodgkin lymphoma should expect to pay between USD 1,200 and USD 1,600 for treatment. For overseas patients, the price ranges from $1,800 to $2,200. The type of treatment employed for a particular patient can affect the cost. The cost may also vary depending on the stage of the cancer at diagnosis.
Chemotherapy and radiation therapy are the main treatments for Hodgkin's lymphoma. Common first-line treatments for advanced stages include chemotherapy regimens such as escalating BEACOPP or ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine). Radiation therapy is frequently used for diseases in their early stages. Immunotherapy medications such as pembrolizumab, nivolumab, and brentuximab vedotin are also used, particularly in instances that have relapsed or are not responding to initial treatment.